Neuromyelitis optica: Devic′s disease

A Case of Neuromyelitis Optica (Devics' Disease)

ages; according to some authors more commonly young females. Pathologically the disease resembles disseminated sclerosis in that there is demyelinization of axis cylinders. The spinal cord shows such diffuse or multiple disseminated lesions. The optic nerves also present the same type of lesions. Clinically the disease is quite distinct from disseminated sclerosis. It is characterized by an acu...

Neuromyelitis Optica

An 11-year-old girl developed sudden visual loss in her left eye, preceding subacute myelitis by 9 months. Multifocal lesions in the central nervous system were demonstrated by magnetic resonance imaging. Although unilateral blindness is unusual, the clinical findings predominantly involving the optic nerve and spinal cord were consistent with the diagnosis of neuromyelitis optica (NMO). This c...

Neuromyelitis Optica (Devic's Disease). A Case Report

Treatment of neuromyelitis optica/neuromyelitis optica spectrum disorders with methotrexate

BACKGROUND To review our experience using methotrexate as a single long-term immunosuppressant (IS) therapy in neuromyelitis optica/neuromyelitis optica spectrum disorders (NMO/NMOSD). METHODS We performed a retrospective chart review of all patients with a diagnosis of NMO/NMOSD, supported by a positive NMO-IgG testing, who were treated with methotrexate. A paired sample 2 tailed t test was ...

A case of neuromyelitis optica (Devic's disease).

Neuromyelitis optica is an inflammatory disease of the central nervous system in which there are episodes of inflammation and damage to the myelin that almost exclusively affect the optic nerves and spinal cord. It usually causes temporary blindness, occasionally permanent, in one or both eyes. It can also lead to varying degrees of weakness or paralysis in the legs or arms, loss of sensation, ...